2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-112559
    Bis-PEG2-acid 19364-66-0 ≥98.0%
    Bis-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Bis-PEG2-acid
  • HY-130216
    THP-PEG3-OH 60221-37-6
    THP-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG3-OH
  • HY-40152
    1-Boc-azetidine-3-yl-methanol 142253-56-3 99.92%
    1-Boc-azetidine-3-yl-methanol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-yl-methanol is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]
    1-Boc-azetidine-3-yl-methanol
  • HY-136158A
    6-Maleimidocaproic acid sulfo-NHS sodium 215312-86-0 98.91%
    6-Maleimidocaproic acid sulfo-NHS (Sulfo-EMCS) sodium is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    6-Maleimidocaproic acid sulfo-NHS sodium
  • HY-W067705
    3,6,9-Trioxaundecanedioic Acid 13887-98-4 ≥98.0%
    369-Trioxaundecanedioic Acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    3,6,9-Trioxaundecanedioic Acid
  • HY-130871A
    HS-PEG3-CH2CH2NH2 hydrochloride
    HS-PEG3-CH2CH2NH2 hydrochloride (Thiol-PEG3-amine hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HS-PEG3-CH2CH2NH2 hydrochloride
  • HY-134704
    Biotin-PEG4-SH 2762393-22-4
    Biotin-PEG4-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG4-SH
  • HY-140004
    Azide-PEG3-Tos 178685-33-1 99.15%
    Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azide-PEG3-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG3-Tos
  • HY-140468
    Boc-N-amido-PEG3-acid 1347750-75-7
    Boc-N-amido-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-N-amido-PEG3-acid
  • HY-133439
    BCN-PEG4-NHS ester
    BCN-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. BCN-PEG4-NHS ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    BCN-PEG4-NHS ester
  • HY-140656A
    Biotin-PEG-Biotin 194920-55-3
    Biotin-PEG-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG-Biotin
  • HY-140199
    Amino-PEG24-Boc 2170987-96-7
    Amino-PEG24-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG24-Boc
  • HY-140070
    endo-BCN-PEG8-NHS ester 1608140-48-2
    endo-BCN-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG8-NHS ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-PEG8-NHS ester
  • HY-23167
    Acid-PEG4-C2-Boc 1835759-85-7 ≥98.0%
    Acid-PEG4-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the inhibition of mTOR.
    Acid-PEG4-C2-Boc
  • HY-140217
    Azido-PEG10-amine 912849-73-1
    Azido-PEG10-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG10-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG10-amine
  • HY-W040214
    m-PEG4-Amine 85030-56-4 98.80%
    m-PEG4-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG4-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG4-Amine
  • HY-141220
    m-PEG12-OH 2050595-03-2 ≥98.0%
    m-PEG12-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-OH is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG12-OH
  • HY-W034597
    20-(tert-Butoxy)-20-oxoicosanoic acid 683239-16-9 ≥98.0%
    20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 20-(tert-Butoxy)-20-oxoicosanoic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
    20-(tert-Butoxy)-20-oxoicosanoic acid
  • HY-130483
    Br-PEG3-C2-Boc 782475-37-0
    Br-PEG3-C2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Br-PEG3-C2-Boc
  • HY-W004697
    Boc-GABA-OH 57294-38-9 ≥98.0%
    Boc-GABA-OH is a PROTAC linker which can be used to synthesis UNC6852, an EED-targeted PROTAC.
    Boc-GABA-OH
PROTAC Linkers Isoform Comparison

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